The Science of Supercritical CO2 Extraction

Cannabis Science Podcast, Episode 12

Supercritical CO2 extraction is one of the most ubiquitous methods for industrial cannabis extraction. But why is that? In the first part of our extraction suite, Dr. Ricardo Rivera, with the help of chemical engineer and producer Dr. Macarena Cataldo, look at the science behind CO2 extraction systems. The benefits, disadvantages, and principals that make this technique so popular. We also have a bit of a surprise at the end, thanks to our resident DJ Kemit Sekhon. Tune in to the end of the show to find out!

Music by KV – Bongo, Kimit – Am

Additional resources and information:


Gallo-Molina A.C. et al. Extraction, isolation and purification of tetrahydrocannabinol from the Cannabis sativa L. plant using supercritical fluid extraction and solid phase extraction. The Journal of Supercritical Fluids. 2019

Citti C. et al. Pharmaceutical and biomedical analysis of cannabinoids: A critical review. Journal of Pharmaceutical and Biomedical Analysis. 2018

Perrotin-Brunel H. et al. Solubility of non-psychoactive cannabinoids in supercritical carbon dioxide and comparison with psychoactive cannabinoids. The Journal of Supercritical Fluids. 2010

Rovetto L. J. Aieta N. V. Supercritical carbon dioxide extraction of cannabinoids from Cannabis sativa L. The Journal of Supercritical Fluids. 2017 Attard T. M. et al. Utilisation of supercritical fluids for the effective extraction of waxes and cannabidiol (CBD) from hemp wastes. Industrial Crops & Products. 2018

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